Illegal fentanyl supply in the United States increases the risk of overdose and acute withdrawal syndrome
Despite US drug overdose deaths declining from 2022 to 2025, the supply of illegal drugs is unpredictable. Illicitly manufactured fentanyl is involved in many deaths and is frequently mixed with other drugs such as benzodiazepines or xylazine. Meditomidine, an alpha-2 adrenergic agonist sedative, more potent and longer-acting than clonidine and xylazine, was first identified in … Read more