illegal

Illegal fentanyl supply in the United States increases the risk of overdose and acute withdrawal syndrome

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Percent of Opioid-Positive Drug Products and Paraphernalia Samples Also Positive for Meditomidine at 20 Sentinel Sites: US Region, July 2025–December 2025 (Interim Data) b,c

Despite US drug overdose deaths declining from 2022 to 2025, the supply of illegal drugs is unpredictable. Illicitly manufactured fentanyl is involved in many deaths and is frequently mixed with other drugs such as benzodiazepines or xylazine. Meditomidine, an alpha-2 adrenergic agonist sedative, more potent and longer-acting than clonidine and xylazine, was first identified in … Read more

Last year more than 750,000 illegal drugs were seized by the HPRA

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A woman performs a subcutaneous self-injection with a semaglutide pen in her abdomen

Last year, the Health Products Regulatory Agency (HPRA) seized more than 750,000 illegal medicines. Figures published by the HPRA confirm that a total of 763,027 food units were seized in 2025. Almost 14,000 individual packages were found to be associated with separate purchases by members of the public of illegal or counterfeit drugs, a threefold … Read more